Directions Directions for children 3-12: Take one (1) chewable tablet at any time of day with or without food. For optimal results continued daily use is suggested. When experiencing occasional digestive upset, two (2) tablets may be taken. If taking two tablets, take one in the morning and one in the evening. If symptoms persist, consult your physician.Storage Instructions: Store Culturelle in a cool, dry place away from direct sunlight.